منابع مشابه
Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases.
GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, differing from each other by 1 to 3 amino acid substitutions that affect substra...
متن کاملGES-11, a novel integron-associated GES variant in Acinetobacter baumannii.
New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.
متن کاملNomenclature of GES-Type Extended-Spectrum -Lactamases
In two recently published articles, Wachino et al. designated a novel ceftazidime-hydrolyzing class A extended-spectrum -lactamase (ESBL) (GES-a) as GES-3 (4), and a new cephamycin-hydrolyzing and inhibitor-resistant class A ESBL (GESb) as GES-4 (5). In actuality, their articles are fraught with misleading nomenclature of GES-type ESBLs and controvertible conclusions on the relationship between...
متن کاملGES-18, a new carbapenem-hydrolyzing GES-Type β-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues.
A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing enzyme GES-5 by a single amino acid substitution (Val80Ile, in the numbering ac...
متن کاملRevolution
After the establishment of written language, the most revolutionary development in human communication was the invention of the printing press in the 15 th century (1). Before then, books were handwritten, rare, and expensive. Medieval monasteries supported the transcription of new manuscripts from existing ones, and errors were common because of spelling, handwriting, and abbreviation idiosync...
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ژورنال
عنوان ژورنال: Italian Journal of Zoology
سال: 2014
ISSN: 1125-0003,1748-5851
DOI: 10.1080/11250003.2014.957024